When your applications has grown very big you might face a problem with performance in this case I had a customer with quite a large crm system that in some cases got very high disk io but the cpu didn’t spike.
neither did the memory almost 50% not used by the system.
So what I did was I increased the memory available for the XPage runtime JVM using HTTPJVMMaxHeapSize
and to get get better database performance I increased the database IO buffers using
also using cacheset tool I increased the amount of memory that Windows will cache files using, this can give you quite a lot of performance because Windows will keep more files in memory instead of reading everything from disk and if you have a newer server with more than 8GB of memory why not use the memory. You can change this when the server is running and find your optimal settings.
You need to trim this depending on how much free memory your server has and you don’t want to run out of memory.
If you have some more tips for the community feel free to comment.